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Synthesis and NMR studies of substituted spiro[5,5]undecanones and derived bicyclic compounds
dc.contributor.advisor | Shapiro, B. L. | |
dc.creator | Luce, Garrett Clements | |
dc.date.accessioned | 2020-08-21T22:03:25Z | |
dc.date.available | 2020-08-21T22:03:25Z | |
dc.date.issued | 1980 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/DISSERTATIONS-644896 | |
dc.description | Typescript (photocopy). | en |
dc.description.abstract | A detailed study has been made into the preparation, structure, and characterization of a series of arylspiro[5,5]undecanones and derived compounds. This family of spiroundecanones is exemplified by the parent structure, A, which was modified to give the polycyclic compounds B. Several ring-cleaved derivatives of type C were also prepared. The general structural features of these systems make them very useful for proton NMR investigations of "perpendicular" or "out-of-plane" diamagnetic ring-current shifts. The axial methylene or R' group at C-5 is in the region of this diamagnetic shielding, and its chemical shift is observed upfield relative to a normal methylene (or vinyl) group. The total magnitude of this upfield shift has been shown to be larger than that of the methyl group shift observed in similar compounds. The primary factor causing differences in these methylene (or vinyl) group shifts has been shown to be the conformational mobility of the group observed, angle factors being of lesser importance, and these results are discussed. In molecules of type B where some functionality is present at the 9 position, the observed shift of the axial C-5 methylene group was not found to be the result of simple addition of aromatic ring current and β-substituent effects. The carbon-13 NMR spectra of all compounds have been measured, and the carbon chemical shift assignments have been tabulated. Aromatic ring-current effects have been shown to be very small, or non-existent, except in the case of edge effects where significant shifting is observed. | en |
dc.format.extent | xiv, 163 leaves | en |
dc.format.medium | electronic | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
dc.subject | Major chemistry | en |
dc.subject.classification | 1980 Dissertation L935 | |
dc.subject.lcsh | Nuclear magnetic resonance spectroscopy | en |
dc.subject.lcsh | Bicyclic compounds | en |
dc.title | Synthesis and NMR studies of substituted spiro[5,5]undecanones and derived bicyclic compounds | en |
dc.type | Thesis | en |
thesis.degree.grantor | Texas A&M University | en |
thesis.degree.name | Doctor of Philosophy | en |
thesis.degree.name | Ph. D | en |
dc.contributor.committeeMember | Harding, K. E. | |
dc.contributor.committeeMember | O'Brien, D. H. | |
dc.contributor.committeeMember | Pace, C. N. | |
dc.type.genre | dissertations | en |
dc.type.material | text | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.identifier.oclc | 7933068 |
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