Abstract
Rate constants for the mutarotation of a-D-giucose and B-D-glucose in dipolar aprotic solvent: N,N-dimethylacetamide (DMAC) in the presence of dodecylammonium propionate is greater by a factor of 2,500 for α-anomer and 5,200 for β-anomer than that in pure solvent. The dependence of the rate constants on water concentration at constant surfactant concentration above the CMC near the saturation kinetic region is atypical of most normal and reversed micellar systems. The observed rate constants decrease linearly as a function of increasing water concentration. In naturally occurring bile salt surfactant systems, I have directed my attention to the hydrolysis and solvolysis of the neutral phosphonate diester. Micellar sodium cholate in dipolar aprotic solvent: dimethylsulfoxide (DMSO) enhance solvolysis rate by a factor of million fold faster than that in pure solvent. Interestingly enough, the dependence of the rate constants on water concentration at constant surfactant concentration in the saturation kinetic region also shows the same behavior as the former surfactant system (DAP in DMAC). Hydrolysis of bis-p-nitrophenyl phenylphosphonate (bis-PNPP) was investigated in 1:1 mole ratio of bile salt (NaC and NaTC) to the fatty acid dodecanoic (lauric) acid. The reaction is linearly dependent on the concentration of hydroxide ion over the pH range (7-10). The significance of these results is discussed critically and comparatively.
Chow, Chung Jea (1976). Interactions and catalysis in normal and reversed micellar systems. Texas A&M University. Texas A&M University. Libraries. Available electronically from
https : / /hdl .handle .net /1969 .1 /DISSERTATIONS -613552.