A study of the pathogenesis of the peripheral neuropathy of experimental coyotillo (Karwinskia humboldtiana), poisoning in goats

Abstract

The pathogenesis of coyotillo (Karwinskia humboldtiana) neuropathy was studied in 26 goats. Twenty-two goats were poisoned with daily oral doses of ground coyotillo fruits, and 4 goats were maintained as controls. Fourteen goats received daily doses of 0.05 per cent, 6 received daily doses of 0.04 per cent, and 2 received daily doses of 0.01 per cent of their body weights. Most of the goats given 0.05 or 0.04 per cent of their body weights were dosed for 6 or 7 days, one of the 2 goats given doses of 0.01 per cent was dosed for 66 days and the other for 69 days. They were killed at various times after their first dosing day. Clinical and neurophysiologic studies included examination of the clinical signs, elicitation of various reflexes, and determination of nerve condition velocity. ...