A clinical, histological and ultrastructural study of the toxic effects of Imidocarb dipropionate in goats

Abstract

The toxic effects of Imidocarb dipropionate were studied in adult Angora goats following the intramuscular injection of a lethal dosage of the drug. The acute clinical signs of toxicosis were transient and included excessive salivation and diarrhea which were attributed to an apparent anticholinesterase activity of the drug. The severe clinical signs of toxicosis to include dyspnea, anorexia and inactivity were observed on days 4 to 8 post-injection (PI) during which time 7 of the goats died and 4 moribund goats were euthanatized. Associated with the severe signs of toxicosis were 1) renal lesions; 2) significant increases in the mean serum urea nitrogen concentrations and serum glutamic oxalacetic transaminase activity; and 3) significant increases in the number of neutrophils. Gross renal lesions included an increase in the size of the kidneys and the presence of alternating white and red streaks radiating from the renal medulla to the cortex. Other gross lesions included pulmonary congestion and edema and excessive fluid in the pleural and peritoneal cavities. Histological lesions in the kidneys progressed rapidly from pyknosis and karyorrhexis of the tubular epithelial nuclei observed at 6 and 12 hours PI to severe acute tubular necrosis of the proximal convoluted tubules on days 1 and 2 PI. ...