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The refined structure of elastase and molecular modelling software
| dc.contributor.advisor | Meyer, Edgar | |
| dc.creator | Cole, Gregory Michael | |
| dc.date.accessioned | 2020-09-02T20:37:06Z | |
| dc.date.available | 2020-09-02T20:37:06Z | |
| dc.date.issued | 1986 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/DISSERTATIONS-16433 | |
| dc.description | Typescript (photocopy). | en |
| dc.description.abstract | A system of macromolecular modelling programs for use on a PDP 11/40 with a Vector General II display device is described. The system allows the user to model interactions between large and small molecules and assists in interpretation of crystallographic electron density maps. The structure of porcine pancreatic elastase (PPE) has been refined using data to 1.65 Angstroms to an R-factor of 17.4% using the aforementioned software system. The details and results of that refinement are reported. The substrate binding site of PPE is compared to those of bovine trypsin and porcine kallikrein with the objective of delineating the role played by the various residues of the binding site in determining the specificity of PPE. | en |
| dc.format.extent | xi, 255 leaves | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | |
| dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.subject | Major biochemistry | en |
| dc.subject.classification | 1986 Dissertation C689 | |
| dc.subject.lcsh | Protein binding | en |
| dc.subject.lcsh | Data processing | en |
| dc.subject.lcsh | Crystallography | en |
| dc.subject.lcsh | Data processing | en |
| dc.subject.lcsh | Elastases | en |
| dc.title | The refined structure of elastase and molecular modelling software | en |
| dc.type | Thesis | en |
| thesis.degree.grantor | Texas A&M University | en |
| thesis.degree.name | Doctor of Philosophy | en |
| thesis.degree.name | Ph. D | en |
| dc.contributor.committeeMember | Gunn, John Martyn | |
| dc.contributor.committeeMember | Pace, Carlos N. | |
| dc.contributor.committeeMember | Scott, Alister Ian | |
| dc.type.genre | dissertations | en |
| dc.type.material | text | en |
| dc.format.digitalOrigin | reformatted digital | en |
| dc.publisher.digital | Texas A&M University. Libraries | |
| dc.identifier.oclc | 17577344 |
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