NOTE: This item is not available outside the Texas A&M University network. Texas A&M affiliated users who are off campus can access the item through NetID and password authentication or by using TAMU VPN. Non-affiliated individuals should request a copy through their local library's interlibrary loan service.
Synthesis and efficacy of dibenzofuran-based diacids and amino acids designed to nucleate parallel and antiparallel beta-sheet formation
| dc.contributor.advisor | Kelly, Jeffery W. | |
| dc.creator | Diaz, Humberto | |
| dc.date.accessioned | 2020-09-02T20:20:08Z | |
| dc.date.available | 2020-09-02T20:20:08Z | |
| dc.date.issued | 1992 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/DISSERTATIONS-1510662 | |
| dc.description | In title, symbol for Greek letter beta is used. | en |
| dc.description.abstract | The synthesis of 4,6-dibenzofurandipropionic acid 18 and 4-(N-tertbutyloxycarbonyl-2-aminoethyl-)-6-dibenzofuranpropionic acid 19, designed to nucleate parallel and antiparallel (β-sheet formation respectively, was accomplished. Compounds 18 and 19 were incorporated into simple diamides and tetraamides in order to evaluate the potential of 18 and 19 to induce intramolecular hydrogen bonding interactions within the amide backbone. FT-IR, variable temperature NMR, and X-ray crystallography studies provided strong evidence for the expected intramolecular hydrogen bonding interactions. Circular dichroism analysis of a water soluble peptide having the sequence Val-Lys-Leu-19-Val-Lys-Leu-NH2 revealed the formation of a significant amount of β- sheet structure. Examination of a series of control peptides demonstrated that the presence of amino acid 19 was essential for (3-sheet structure formation. | en |
| dc.format.extent | xi, 76 leaves | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | |
| dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.subject | Major chemistry | en |
| dc.subject.classification | 1992 Dissertation D542 | |
| dc.subject.lcsh | Nucleation | en |
| dc.subject.lcsh | Dibenzofurans | en |
| dc.subject.lcsh | Synthesis | en |
| dc.subject.lcsh | Proteins | en |
| dc.subject.lcsh | Structure | en |
| dc.subject.lcsh | Hydrogen bonding | en |
| dc.title | Synthesis and efficacy of dibenzofuran-based diacids and amino acids designed to nucleate parallel and antiparallel beta-sheet formation | en |
| dc.type | Thesis | en |
| thesis.degree.grantor | Texas A&M University | en |
| thesis.degree.name | Doctor of Philosophy | en |
| thesis.degree.name | Ph. D | en |
| dc.contributor.committeeMember | Barton, Derek H. R. | |
| dc.contributor.committeeMember | Hayes, Timothy K. | |
| dc.contributor.committeeMember | Lindahl, Paul A. | |
| dc.type.genre | dissertations | en |
| dc.type.material | text | en |
| dc.format.digitalOrigin | reformatted digital | en |
| dc.publisher.digital | Texas A&M University. Libraries | |
| dc.identifier.oclc | 33935190 |
Files in this item
This item appears in the following Collection(s)
-
Digitized Theses and Dissertations (1922–2004)
Texas A&M University Theses and Dissertations (1922–2004)
Request Open Access
This item and its contents are restricted. If this is your thesis or dissertation, you can make it open-access. This will allow all visitors to view the contents of the thesis.