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Preparation, characterization and in vivo evaluation of two hemoglobin-based blood substitutes
| dc.contributor.advisor | DeLoach, John R. | |
| dc.contributor.advisor | McCrady, James D. | |
| dc.creator | Sheffield, Cynthia Lee | |
| dc.date.accessioned | 2020-08-21T22:10:16Z | |
| dc.date.available | 2020-08-21T22:10:16Z | |
| dc.date.issued | 1990 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/DISSERTATIONS-1117207 | |
| dc.description | Typescript (photocopy). | en |
| dc.description.abstract | 1. The controlled hypoosmotic dialysis ultrafiltration (CDU) system described in this work can be used to isolate large quantaties of ultrapure, lipid-free hemoglobin from the red blood cells of a variety of mammals. 2. A nonantigenic blood substitute with a intravenous retention time of at least 14 days can be produced by polymerization of bovine hemoglobin isolated by CDU. 3. The P50 of polymerized bovine hemoglobin can be returned to levels equivalent to that of bovine whole blood by binding IHP to the polyhemoglobin. 4. IHP modified polymerized bovine hemoglobin is not a suitable blood substitute material. | en |
| dc.format.extent | viii, 106 leaves | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | |
| dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.subject | Major veterinary physiology | en |
| dc.subject.classification | 1990 Dissertation S542 | |
| dc.subject.lcsh | Blood substitutes | en |
| dc.subject.lcsh | In vivo | en |
| dc.subject.lcsh | Evaluation | en |
| dc.subject.lcsh | Hemoglobin | en |
| dc.subject.lcsh | Cattle | en |
| dc.subject.lcsh | Analysis | en |
| dc.subject.lcsh | Cattle | en |
| dc.subject.lcsh | In vivo | en |
| dc.subject.lcsh | Blood substitutes | en |
| dc.title | Preparation, characterization and in vivo evaluation of two hemoglobin-based blood substitutes | en |
| dc.type | Thesis | en |
| thesis.degree.grantor | Texas A&M University | en |
| thesis.degree.name | Doctor of Philosophy | en |
| thesis.degree.name | Ph. D | en |
| dc.contributor.committeeMember | Corrier, Don | |
| dc.contributor.committeeMember | Witzel, Don | |
| dc.type.genre | dissertations | en |
| dc.type.material | text | en |
| dc.format.digitalOrigin | reformatted digital | en |
| dc.publisher.digital | Texas A&M University. Libraries | |
| dc.identifier.oclc | 23005969 |
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