Developmental Regulation of Pyrimidine Biosynthesis in Dictyostelium discoideum
Abstract
The research reported in this thesis demonstrates that the initial steps for pyrimidine biosynthesis in the cellular slime mold Dictyostelium discoideum are catalyzed by the enzymes carbamoyl phosphate synthetase (CPSase, EC 2.7.2.9) and aspartate transcarbamoylase (ATCase, EC 2.1.3.1). Furthermore, it has been observed that the crude cell-free extract from Oictyostelium discoideum possesses a non-dialyzable inhibitory component of CPSase. It was striking to note that this inhibitory component interfered with CPSase activity from Escherichia coli as well.
Description
Program year: 1981/1982Digitized from print original stored in HDR
Subject
Dictyostelium discoideumcellular slime mold
carbamoyl phosphate synthetase
CPSase
aspartate transcarbamoylase
ATCase
non-dialyzable inhibitory component
Citation
Jones, Brenda L. (1982). Developmental Regulation of Pyrimidine Biosynthesis in Dictyostelium discoideum. University Undergraduate Fellow. Available electronically from https : / /hdl .handle .net /1969 .1 /CAPSTONE -WillardR _1998.