Effects of the Mycotoxin Penicillic Acid on Electrogenic Sodium Transport and Associated Adenosine Triphosphatase
Abstract
The effects of the mycotoxin penicillic acid on short circuited intact toad bladder and on Na⁺-K⁺, activated ATPase were examined to determine the relationship between toxin, the Na⁺-K⁺ ATPase enzyme system and associated active sodium transport. Penicillic acid inhibited transbladder short circuit current and Na⁺-K⁺ ATPase from isolated bladder preparations. The effect was time and dose dependent. The results are compatible with the assumption that Na⁺-K⁺ ATPase is associated with the pump mechanism since penicillic acid inhibited enzyme activity and reduced the rate of electrogenic Na⁺ transport.
Description
Program year: 1981/1982Digitized from print original stored in HDR
Citation
Wilczynski, Teresa Ann (1982). Effects of the Mycotoxin Penicillic Acid on Electrogenic Sodium Transport and Associated Adenosine Triphosphatase. University Undergraduate Fellow. Available electronically from https : / /hdl .handle .net /1969 .1 /CAPSTONE -PinkstonD _1978.