| dc.description.abstract | The purpose of this study was to compare the action of various drugs on gastric retention (Experiment 1) and food intake (Experiment 2). The subjects were 79 Sprague-Dawley male albino rats. (Experiment 1 = 40), (Experiment 2 = 39). In Experiment 1, the rats consumed a pellet meal and were then injected (IP) with saline or either (30 mg/kg) of l-PPA, d-PPA, 1- norpseudoephedrine or d-norpseudoephedrine. The rats treated with saline, d-norpseudoephedrine, l-norpseudoephedrine and d-PPA exhibited a marked clearance of food. The rats treated with 1- PPA detained a large portion of the test meal, indicating that 1- PPA is indeed effective in the inhibition of gastric emptying. In Experiment 2, the rats were first injected (IP) with saline or either (30 mg/kg) of l-PPA, d-PPA, l-norpseudoephedrine or dnorpseudoephedrine. After injection, the rats consumed a pellet meal. The rats treated with d-PPA exhibited a normal amount of grams consumed. The rats treated with l-norpseudoephedrine and d-norpseudoephedrine displayed a small but not significant decline in food intake. The l-PPA drug group demonstrated a significant reduction in food intake. This data concludes that l-PPA is not only effective in gastric inhibition, but effective in the reduction of food intake and that the former may mediate the latter as well. | en |
