The Effect Of A Beta Adrenergic Agonist, Isoproterenol, And An Anticholinesterase, Eserine, On Ethanol-Induced Intoxicatione In The Rat
Abstract
This study was designed to determine the effects of eserine and isoproterenol on ethanol-induced intoxication in the rat. The cortical EEG (recording from the frontal and occipital lobes), four behavioral tests, and a coordination test were used as indicators of intoxication. Eserine (0.2 mg/kg) blocked the ethanol-induced deactivation of the EEG, but the animals remained behaviorally intoxicated.
Isoproterenol (0.05, 0.1, 0.2 mg/kg) caused a decrease in the ethanol deactivation and behaviorally blocked intoxication. Isoproterenol by itself deactivates the EEG. Propranolol (10 mg/kg), a Beta blocker, potentiated the effect of ethanol, both by an increase in deactivation and an increase in the intoxication state. It was concluded that isoproterenol antagonizes the action of ethanol.
Description
Program year: 1977/1978Digitized from print original stored in HDR
Citation
Oeffinger, Kevin Charles (1978). The Effect Of A Beta Adrenergic Agonist, Isoproterenol, And An Anticholinesterase, Eserine, On Ethanol-Induced Intoxicatione In The Rat. University Undergraduate Fellow. Available electronically from https : / /hdl .handle .net /1969 .1 /CAPSTONE -HsiehCT _1990.