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dc.contributor.advisorMurphy, Keith E.en_US
dc.creatorTsai, Kate Leanneen_US
dc.date.accessioned2007-04-25T20:11:21Z
dc.date.available2007-04-25T20:11:21Z
dc.date.created2005-12en_US
dc.date.issued2007-04-25
dc.identifier.urihttp://hdl.handle.net/1969.1/4878
dc.description.abstractThe morphologic variability seen in the domestic dog, Canis lupus familiaris, is unique among mammals. Selective pressures imposed by humans have divided dogs into almost 400 separate breeds. Selection has also led to the development of approximately 450 hereditary diseases, many of which are limited to specific breeds. Over half of these diseases present with similar clinical characteristics to those of many human hereditary diseases, making the dog an ideal model for study of the genetic bases of such diseases. Many diseases do not have candidate genes or have too many candidates to characterize. This is exacerbated in complex diseases that are caused by several genes. Whole-genome scans can provide insight into diseases by identifying marker(s) that co-segregate with a disease phenotype. The Minimal Screening Set - 2 (MSS-2) is the most recent set of microsatellites suitable for whole-genome screens. The first objective of this work was to streamline genomic screens in order to efficiently analyze large numbers of animals. To this end, chromosome-specific microsatellite panels were developed for the MSS-2. Canine hip dysplasia (CHD) is the most common orthopedic disease of the dog. CHD primarily affects medium and large breed dogs, but is found in almost every breed. The major objective of this work was to use linkage analysis to identify chromosomal regions that contain genes that are involved in CHD. Two populations were screened using the MSS-2. The first was a small family of Boykin Spaniels, though no markers were statistically significant in a whole-genome screen. An outcrossed pedigree of Greyhound/Labrador Retrievers was created for quantitative trait loci (QTL) mapping of CHD. The informativeness of markers in the F2 and backcrossed generations were calculated to show the utility of using such a population. Other factors that affect the power of this pedigree to identify QTL were also highlighted. Chromosomes that were identified in a previous screen as harboring putative QTLs were examined using the chromosome-specific panels to further define and confirm the regions of interest. Although no markers reached statistical significance, several areas of interest were identified.en_US
dc.format.extent1273045 bytes
dc.format.mediumelectronicen_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherTexas A&M Universityen_US
dc.subjectcanineen_US
dc.subjectgeneticsen_US
dc.subjecthip dysplasiaen_US
dc.subjectmicrosatelliteen_US
dc.titleGenetic analysis of canine hip dysplasiaen_US
dc.typeBooken
dc.typeThesisen
thesis.degree.departmentVeterinary Pathobiologyen_US
thesis.degree.disciplineVeterinary Microbiologyen_US
thesis.degree.grantorTexas A&M Universityen_US
thesis.degree.nameDoctor of Philosophyen_US
thesis.degree.levelDoctoralen_US
dc.contributor.committeeMemberCredille, Kelly M.en_US
dc.contributor.committeeMemberKerwin, Sharon C.en_US
dc.contributor.committeeMemberWomack, James E.en_US
dc.type.genreElectronic Dissertationen_US
dc.type.materialtexten_US
dc.format.digitalOriginborn digitalen_US


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