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dc.contributor.advisorCremer, Paul S.
dc.creatorHolden, Matthew Alexander
dc.date.accessioned2004-09-30T02:02:05Z
dc.date.available2004-09-30T02:02:05Z
dc.date.created2005-05
dc.date.issued2004-09-30
dc.identifier.urihttp://hdl.handle.net/1969.1/458
dc.description.abstractHerein is presented the collective experimental record of research performed in the Laboratory for Biological Surface Science. These investigations are generally classified under the category of bioanalytical surface science and include the following projects. Chapters III and IV describe the creation of a microfluidic device capable of generating fixed arrays of concentration gradients. Experimental results were matched with computational fluid dynamics simulations to predict analyte distributions in these systems. Chapters V and VI demonstrate the discovery and utility of photobleaching fluorophores for micropatterning applications. Bleached fluorophores were found to rapidly attach to electron rich surfaces and this property was used to pattern enzymes inside microfluidic channels in situ. Finally, Chapter VII exhibits a method by which solid supported lipid bilayers can be dried and preserved by specifically bound proteins. The intrinsic property of lateral lipid mobility was maintained during this process and a mechanism by which the protein protects the bilayer was suggested.en
dc.format.extent6885529 bytesen
dc.format.mediumelectronicen
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherTexas A&M University
dc.subjectmicrofluidicsen
dc.subjectphotopatterningen
dc.subjectenzymesen
dc.subjectfluorescenceen
dc.titleStudies in biological surface science: microfluidics, photopatterning and artificial bilayersen
dc.typeBooken
dc.typeThesisen
thesis.degree.departmentChemistryen
thesis.degree.disciplineChemistryen
thesis.degree.grantorTexas A&M Universityen
thesis.degree.nameDoctor of Philosophyen
thesis.degree.levelDoctoralen
dc.contributor.committeeMemberBeskok, Ali
dc.contributor.committeeMemberVigh, Gyula
dc.contributor.committeeMemberCrooks, Richard M.
dc.type.genreElectronic Dissertationen
dc.type.materialtexten
dc.format.digitalOriginborn digitalen


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