Studies of phase separable soluble polymers
MetadataShow full item record
The technique of phase labeling has the ability to greatly enhance synthetic protocol by simplifying purification and increasing efficiency. Traditional insoluble supports offer efficient and simple recovery of the Âphase taggedÂ material but suffer from problems inherent to their heterogeneous nature. A solution to these problems has been to utilize phase separable soluble polymers in the design of ÂsmartÂ responsive systems that offer the option of homogenous reaction conditions with heterogeneous separation conditions. The subject of this dissertation focuses on the application of soluble polymeric phase tags in systems where the miscibility between solid-liquid and liquid-liquid systems is thermally induced. Low molecular weight poly(ethylene glycol) (PEG) oligomers were investigated as phase anchors for SCS palladacycle catalysts. The oligomeric PEG chains were sufficient to engender polar phase solubility in a heptane-DMA thermomorphic system. Microwave irradiation of these thermomorphic mixtures of palladium complexes and substrates was a viable scheme to recycle and significantly shorten reaction times for simple Heck reactions of aryl iodides. Soluble polymeric supports possessing a lower critical solution temperature (LCST) were utilized in the sequestration of the S-triazine herbicide, atrazine, from contaminated water samples. The ability of poly(N-isopropylacrylamide) to sequester hydrophobic guests like atrazine was examined. A functionalized PNIPAM derivative containing secondary cyclic amines exhibited superior sequestration ability that was credited to the covalent binding of the atrazine. In order to facilitate the design of tailored, thermally responsive, smart polymers, a high throughput temperature gradient microfluidic device was used to obtain LCST data in a fast, accurate manner. The specific ion effects of various alkali metal halide salts on the LCST of PNIPAM were investigated. The high precision in the measurements enabled more subtle effects such as changes in solvent isotope, polymer microstructure, molecular weight, and importance of end group effects on the LCST of poly(N-alkylacrylamide)s to be evaluated.
Furyk, Steven Michael (2003). Studies of phase separable soluble polymers. Doctoral dissertation, Texas A&M University. Texas A&M University. Available electronically from