| dc.creator | Petrich, Christine | |
| dc.date.accessioned | 2006-08-16T14:01:33Z | |
| dc.date.available | 2006-08-16T14:01:33Z | |
| dc.date.issued | 2006-08-16 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/3701 | |
| dc.description.abstract | The eventual outcome of spinal cord injury is largely influenced by damage that occurs after the injury. Damaged connections between spinal cord cells and the brain allow a positive feedback mechanism to go unchecked when activated by ascending pain messages. Over-excitation then causes secondary damage. This study examines whether a pharmacological manipulation that should attenuate over-excitation reduces the adverse effects of shock treatment. Rats received spinal impact injuries and, the next day, were given the NMDA receptor antagonist MK-801 (0.08 mg/kg, i.p.) or its vehicle before receiving either a bout of uncontrollable stimulation or identical treatment without the stimulation itself. Their hindlimb motor activity was monitored for 21 days. Results indicate a significant effect of the drug on rats that received uncontrollable stimulation. The study has clinical implications for the treatment of spinal cord injuries in humans. | en |
| dc.description.sponsorship | Office of Honors Programs and Academic Scholarships
National Institute of Neurological Disorders and Stroke Grant NS41548 | en |
| dc.format.extent | 329884 bytes | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en_US | |
| dc.title | Effect of the NMDA receptor antagonist MK-801 on recovery from spinal cord injury in rats given uncontrollable stimulation | en |
| dc.type.genre | Thesis | en |
| dc.type.material | text | en |
| dc.format.digitalOrigin | born digital | en |
