Browsing Undergraduate Research Scholars Capstone (2006–present) by Department "Biochemistry and Biophysics"
Now showing items 1-20 of 27
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(2018-04-19)Previous research indicates that Set1 is the catalytically active protein in COMPASS, a protein methyltransferase complex associated with transcription in budding yeast cells. However, the mechanistic role that Set1 and ...
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Clostridioides difficile (C. difficile), the microbe responsible for Clostridioides difficile infection (CDI), is a common nosocomial infection that exerts its pathogenicity primarily by two toxins, TcdA and TcdB. Designed ...
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(2019-04-29)As the issue of bacterial antibiotic resistance becomes more prevalent, phage technology research attempts to investigate viruses to possibly target and kill pathogens effectively with specificity. This study is an ...
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Telomeres consist of repeating sequences of nucleotides at the end of linear chromosomes and associated proteins that together serve to protect chromosome ends from degradation or fusion. Misregulation of telomeres leads ...
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(2021-04-27)Astrocytes are the most populous cell type in the central nervous system (CNS) and are vital in neuron development, regulating blood flow, and maintaining communication between neurons. Astrocytic control on the CNS is due ...
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The goal of this project is to develop methods to manipulate the genome of Peromyscus maniculatus for the future eradication of diseases such as Hantavirus and Lyme disease that this species can transmit to humans. The ...
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Botryococcus braunii is a green microalga that is capable of producing large amounts of liquid hydrocarbons that can be processed into liquid fuels such as gasoline, kerosene and diesel. Lycopaoctaene is a C40 hydrocarbon ...
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(2017-04-28)With an ever-increasing incidence of antibiotic resistance in clinical settings, bacterial viruses, or “phages”, are being considered as alternatives to chemical antibiotics. One type of phage in particular, single-stranded ...
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The genotypic factors that affect antler size in whitetail deer are currently unknown. Environmental factors, such as nutrition, have been studied and have been shown to affect antler size, but the role of genomic variation ...
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(2017-04-28)Disease decreases production efficiency and kills millions of animals across all types of livestock operations every year. This is severely detrimental to both animal producers and consumers from an economic and overall ...
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(2010-12-08)Intrinsically disordered proteins lack a rigid structure due to their simple amino acid sequence. Because of their multiple roles, disordered proteins often account for a majority of proteins known to be associated with ...
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Replication protein A (RPA) and CST are two highly similar heterotrimeric telomere complexes involved in various aspects of DNA metabolism. RPA functions in genome-wide DNA metabolism (including DNA replication, repair and ...
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Molecular, Genetic, and Biochemical Analysis of the Phikt Disruptin: A New Class of Lysis Proteins (2019-05-03)Phages are the viruses of bacteria. To complete the infection cycle, phages produce lysis proteins to overcome the bacterial cell envelope. The final barrier in Gram-negative hosts is the outer membrane (OM). We have ...
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Raman Spectroscopy Enables Highly Accurate Differentiation Between Young Male and Female Hemp Plants Determination of hemp (Cannabis sativa) sexuality is an integral part of the hemp industry. Current methods of analysis can be costly and invasive. Genetic testing is most often required which involves sending leaf samples ...
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Antibiotic discovery has stagnated. To avoid catastrophe, it must speed up. One of the most heavily used methods of drug discovery is high-throughput screening, yet in the 40 years of use of high-throughput screening, zero ...
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(2012-05-03)Galectins belong to a family of endogenous lectins with affinity for β-galactosidase-containing oligosaccharides. They are differentially expressed by several types of cells of the immune system in vertebrate organisms. ...
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(2017-04-25)The lymphatic system is a network of capillaries, vessels, and nodes that span the length of our entire body. Lymphatic capillaries uptake immune cells, fluid, and macromolecules from the interstitium and transport this ...
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(2018-04-19)Mediator is a protein complex in eukaryotes which integrates signals from a diverse range of transcription factors and relays them to RNA polymerase. Much of mediator is highly conserved, but it is expected that some ...
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(2010-05-06)My research aims to investigate how reactive oxygen species(ROS) induced transcription factors NFKB, ATF-2 and RUNX-2 affect expression of 2OST. 2OST is a sulfotransferase responsible for sulfation of the heparan sugar ...
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(2018-05-02)Antibacterial drug resistance is a major factor in the increasing rate of failure to successfully treat diseases such as tuberculosis (TB). The World Health Organization estimates that in 2015 a total of 10.4 million new ...