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Now showing items 111-120 of 147
INHIBITOR STUDIES ON MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE
(2008-08-03)
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which ...
Survey of Brain Variations of Young Adult and Aged B2 (-/-) Knockout Mice
(2008-07-16)
Neuronal nicotinic acetylcholine receptors (nAChRs) are pentameric, ligand-gated ion channels whose activation is triggered by the neurotransmitter acetylcholine and by the exogenous compound, nicotine. In previous studies, ...
Searching for Dark Matter in Particle Physics Experiments
(2008-05-25)
Astronomical observations have shown that the amount of visible matter
in the universe comprises only a fraction of the total mass of the
universe. This extra mass is described as ``dark
matter''. In this thesis we ...
Effects of Prenatal Methylmercury Exposure on Motor Coordination, Activity Levels and Mitochondrial Membrane Potential in Adult Mice
(2006-08-16)
Methylmercury has cytotoxic effects on animals and humans and a major target
organ for methylmercury is the central nervous system (CNS). Methylmercury
(MeHg) is a developmental neurotoxicant and the prenatal CNS appears ...
EXPRESSION OF BRUCELLA GENES REQUIRED FOR LIPOPOLYSACCARIDE PRODUCTION UNDER THE CONTROL OF ARAC AND PTAC PROMOTERS
(2006-08-16)
Brucella spp. are gram-negative, facultative intracellular pathogen that causes an infectious and contagious bacterial disease, brucellosis, in humans and animals. Previous research showed that lipopolysaccaride (LPS) is ...
Effect of the NMDA receptor antagonist MK-801 on recovery from spinal cord injury in rats given uncontrollable stimulation
(2006-08-16)
The eventual outcome of spinal cord injury is largely influenced by damage that occurs after the injury. Damaged connections between spinal cord cells and the brain allow a positive feedback mechanism to go unchecked when ...
Museum Culture in the Anglo-American Atlantic World, c. 1750-1815
(2006-08-16)
During the late eighteenth century and early nineteenth centuries, the Anglo-American Atlantic world saw a rise in the number and popularity of museums as cultural institutions. By concentrating on the premier museums in ...
OPTICAL BIOPSY: COMPLEMENTING HISTOLOGY WITH NONLINEAR OPTICAL MICROSCOPY
(2006-08-16)
Histology, though widely used for cellular imaging, suffers from its destructive nature; cells are not viewed in their natural living environment. Nonlinear optical microscopy (NLOM) has been widely used to view cells in ...
The Visual Impetus and the Writings of J.R.R. Tolkien
(2006-08-16)
Visual illustrations were critical to Tolkien's creativity—they preceded his creation of lexical texts, helped to define the world in which he set most of his literature, and continued to hold a great significance in the ...
Vacuum Energy in Quantum Graphs
(2007-07-14)
We calculate the vacuum energy in quantum graphs. Vacuum energy arose in quantum physics but has an independent mathematical interest as a functional carrying information about the eigenvalue spectrum of a system. A quantum ...