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Evaluation of unmarked deletion mutants as improved Brucella vaccine strains in the mouse and goat models
(Texas A&M University, 2006-10-30)
Historical data suggests that prolonged survival of Brucella vaccine organisms in
the target host enhances immune protection. Recent research has focused upon the
development of rough vaccine strains to avoid interference ...
Concerning Brucella LPS: genetic analysis and role in host- agent interaction
(Texas A&M University, 2006-10-30)
B rucella lipopolysaccharide is an important component of virulence in
brucellosis. Recent research in macrophage models has shown that Brucella
LPS does not behave like classical LPS by stimulating potent inflammatory
responses. ...
Utilization of the persistent nature of Brucella in the development of live vaccines
(Texas A&M University, 2006-10-30)
The roles of genes responsible for the survival and persistence of Brucella in the
host and the relationship between these genes and the disease were investigated via
signature-tagged transposon mutagenesis. As much as 8% ...