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Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors
(2009-05-15)
Estrogen receptor α (ERα) is a ligand activated transcription factor. Many widely
used synthetic compounds and natural chemicals can activate ERα. The
compounds investigated in this study include 17β-estradiol (E2), ...
Role of estrogen receptor alpha (ER alpha) insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells
(2009-05-15)
Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation and activation of kinase pathways in MCF-7 breast cancer cells. The role of estrogen receptor α (ERα) in mediating responses induced ...
The Role of single minded 2 short in mammary gland development and breast cancer
(2009-05-15)
Single minded 2 (Sim2) is a member of the basic helix-loop-helix Per-ARNT-Sim
(Period-Arylhydrocarbon Nuclear Translocator-Single minded) family. Human SIM2 is
involved in the etiology of the Down’s phenotype. In addition ...
Mechanisms of growth inhibition induced by methylene-substituted and ring-substituted dims in breast cancer cells
(2009-05-15)
One in 8 women will be diagnosed with breast cancer in the United States and
estrogen receptor (ER) status largely influences the type and subsequent success of
treatment employed. Although ER-positive breast cancer can ...