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Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese
(2009-05-15)
The domestic dog, Canis lupus familiaris, is a unique model system for the dissection of hereditary diseases. Selective breeding practices have created more than 300 distinct breeds of dogs, born from a desire to create ...
Genetic analysis of canine hip dysplasia
(Texas A&M University, 2007-04-25)
The morphologic variability seen in the domestic dog, Canis lupus familiaris, is
unique among mammals. Selective pressures imposed by humans have divided dogs into
almost 400 separate breeds. Selection has also led to the ...
Understanding the genetics of aging: a canine model
(Texas A&M University, 2007-04-25)
As life expectancy in the United States increases each year, the percentage of the
population that is comprised of aged individuals rises also. Researchers expect the
largest increase in population to occur in the segment ...
Assessment of the canine intestinal microflora using molecular methods and serum markers
(Texas A&M University, 2007-04-25)
Previous studies examining the canine intestinal microflora have focused on
cultivation of bacteria from intestinal content. Recently, it has been recognized that the
majority of bacteria cannot be identified using standard ...
MicroRNA expression in canine mammary cancer
(Texas A&M University, 2008-10-10)
MicroRNAs (miRNAs) play a vital role in differentiation, proliferation and tumorigenesis by binding to messenger RNAs (mRNA) and inhibiting translation. To initiate an investigation into the identification of miRNAs in the ...
Identification of a mutation in COL4A5 causative for X-linked Alport syndrome in the domestic dog and analysis of gene expression in the kidneys of affected and nonaffected siblings
(Texas A&M University, 2004-09-30)
The domestic dog, Canis lupus familiaris, plays many roles in the lives of humans. Additionally, the dog is recognized for its potential as a model for many human hereditary diseases. Thus, the genetics and genomics of the ...
Characterization of the mutation causative for autosomal recessive hereditary nephropathy in the english cocker spaniel and analysis of gene expression in multiple models of hereditary nephropathy
(2009-05-15)
The domestic dog, Canis familiaris, has over 450 naturally occurring inherited diseases. Over half of these diseases are clinically similar to human diseases making the dog an excellent model in which to study human ...
In vitro and in vivo analysis of differential gene expression between normal norfolk terrier dogs and those with an autosomal recessive mutation in KRT10
(Texas A&M University, 2005-11-01)
Natural diseases caused by keratin mutations are rare and have only been reported in humans. We have recently identified a heritable skin disorder in Norfolk terriers caused by a mutation in KRT10. Affected dogs have a ...
Development of a multiplexing strategy for whole genome scans of the domestic dog and analysis of hereditary deafness in the Dalmatian
(Texas A&M University, 2005-08-29)
The Dalmatian is affected by deafness more than any other breed of domestic dog, with 30% of the United States population suffering from unilateral or bilateral deafness. The genetic origin of deafness in the Dalmatian is ...