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Aerosol matrix-assisted laser desorption ionization mass spectrometry
(1995)
Our laboratory has developed a technique that uses a pneumatically generated aerosol to combine liquid introduction with matrix-assisted laser desorption ionization (MALDI) mass spectrometry. The work described here ...
Syntheses of linear tetrapyrroles as potential inhibitors for uroporphyrinogen III synthase
(1992)
Living systems depend on a variety of metal complexes of tetrapyrrolic macrocycles to carry out many biologically important functions. Among these pigments of life are heme, chlorophyll and vitamin B[12]- All these substances ...
Synthesis of substrates and analogs for the enzymes of vitamin B₁₂ biosynthesis
(1990)
The synthesis of some of the postulated intermediates in the pathway of vitamin B12 biosynthesis, precorrins-4A, -4B and -5, were initiated. The different ring precursors necessary for the precorrins were prepared as racemic ...
Enzyme catalyzed oxido-reductive reactions : synthetic applications and mechanistic studies
(1992)
Chapter II describes the synthetic application of a non-heme monooxygenase from Pseudomonas oleovorans (POM) toward the preparation of a series of epoxides from their protected allylic alcohol precursors. Like other ...
Discovery of a labile nickel ion required for CO/acetyl-CoA exchange activity in the NiFe complex of carbon monoxide dehydrogenase
(1992)
The oxygen-sensitive, nickel and iron-containing enzyme carbon monoxide dehydrogenase (CODH) from clostridium thermoaceticum was purified without any significant loss of the activity present in the crude extract. The careful ...
Theoretical and physical investigations of group 9-14 metal complexes containing the diphenylmethylenethiophosphinate (MTP) ligand : effect of metal proximity on physical properties
(1993)
A trimetallic complex, [Hg2Pt(CH2P(S)Ph2)4]X2 (X = BPh4-, PF6-, 1a , b), was obtained from the reaction of Hg(MTP)2 (MTP = CH2P(S)Ph2-) with one equivalent of Pt[S(CH2CH3)2]2Cl2, in CH2Cl, in the presence of either NaBPh4 ...
Probing the relationship between the acid-induced denaturation of Transthyretin and amyloidosis
(1993)
The pH-induced denaturation of Transthyretin (TTR) was studied in order to understand the biochemical basis of TTR's amyloidogenicity. The structural changes were monitored by UV, circular dichroism, and fluorescence ...
The synthesis and characterization of mixed derivative single phase solid solutions of divalent and trivalent metal ions
(1993)
This dissertation presents the synthesis, characterization and reactivity of layered mixed derivative solid solutions of divalent and trivalent metal phosphonates, namely the phenylphosphonate phosphite mixed derivatives ...
Surface modification of polyolefins using new synthetic techniques
(1992)
A new technique for functionalization of polyolefin surfaces using C-H bond activation catalysts has been developed. The Gif system which was developed by the Barton group as a model of methane monooxygenase has been ...