Now showing items 1-20 of 332
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(2020-03-26)In most organisms, threonine deaminase (TD) functions as a housekeeping enzyme to convert threonine to α-ketobutyrate and ammonia as the committed step in the biosynthesis of isoleucine (Ile). However, tomato plants have ...
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(2019-01-14)Isocitrate lyase 1 & 2 are essential enzymes for Mycobacterium tuberculosis pathogenicity and antibiotic resistance, and thereby, are appealing targets for the treatment of latent tuberculosis. Since high-throughput screening ...
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(2012-10-19)The AGC group of protein kinases (named for protein kinases A, G, and C) is found in all eukaryotes studied so far, and its members coordinate essential cellular processes including translation, metabolism, hormone response, ...
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(2022-07-27)The intersection of protein and lipid biology is of growing importance for understanding how cells respond to changes in structural needs during adhesion and migration. While protein complexes engaged with the cytoskeleton ...
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(2022-02-02)Our understanding of gene essentiality in Mycobacterium tuberculosis (Mtb) has improved over the years. The introduction of these gene products into target-based drug discovery campaigns depends, in part, on whether or not ...
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(2021-07-23)The single-celled pathogens Mycobacterium tuberculosis and Trypanosoma cruzi are the causative agents of the human diseases tuberculosis and Chagas disease, respectively. In an effort to develop potentially new treatments ...
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(2013-07-24)β-lactamase enzymes catalyze the irreversible hydrolysis of the four-membered cyclic amide ring characteristic of β-lactam antibiotics rendering them inactive and useless against pathogenic bacteria. Understanding structure ...
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(Texas A&M University, 2006-08-16)Most proteins residing in the mitochondrial matrix are synthesized in the cytosol and post-translationally imported into the mitochondrial matrix. The matrix-targeted preproteins traverse the outer mitochondrial membrane ...
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(2021-04-07)Phosphoinositides (PIPs) are phosphorylated derivatives of a membrane lipid called phosphatidylinositol that act as signaling molecules. These signaling molecules regulate hundreds of biological events ranging from growth, ...
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(2013-07-19)Pseudomonas syringae delivers a plethora of effector proteins into host cells to sabotage host immune responses and physiology to favor infection. We have previously shown that P. syringae pv. tomato DC3000 effector HopF2 ...
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(2018-05-04)Decision-making influences the development of life over multiple levels. Understanding the core mechanisms of this complex process could yield new insights into the treatment of diseases and the evolution of lifeforms. To ...
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(Texas A&M University, 2005-11-01)The N-terminal hydrophobic domain of the phage P1 endolysin Lyz was found to facilitate the export of Lyz in a sec-dependent fashion, explaining the ability of Lyz to cause lysis of E.coli in the absence of the P1 holin. ...
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(2009-05-15)T4 requires two proteins: holin, T (lesion formation and lysis timing) and endolysin, E (cell wall degradation) to lyse the host at the end of its life cycle. E is a cytoplasmic protein that sequestered away from its ...
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(2009-05-15)The fate of phage-infected bacteria is determined by the holin, a small membrane protein that triggers disruption of the membrane at a programmed time, allowing a lysozyme to attack the cell wall. S2168, the holin of phage ...
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(2012-10-19)NmtR and AdcR belong to two structural and functional classes of transcriptional metalloregulators. The present study shows that AdcR is a novel Zn(II) dependent repressor and the first ever metalloregulator of the MarR ...
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(2014-06-12)Tuberculosis is one of the leading causes of death due to infectious disease. The causative agent, Mycobacterium tuberculosis, is a facultative intracellular parasite with a slow regeneration rate. Though there is a decline ...
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(2016-09-23)Alternative sources of fuel such as bioethanol offer benefits such as energy independence and stability, reduction in green house gas emissions, and are a renewable resource. The C4 grasses are large contributors of ...
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(2023-01-06)Bioenergy sorghum has a high biomass yield potential, is drought resilient, has good nitrogen use efficiency, and has a root system that contributes to the accumulation of soil organic carbon. In this dissertation, field ...
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(2022-06-22)Iron (Fe) is essential for most forms of life due to its unique redox and substrate binding properties. It is also dangerous since it can generate reactive oxygen species (ROS). In Saccharomyces cerevisiae, 95 known Fe ...
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(Texas A&M University, 2004-09-30)The HPr proteins were characterized as folding by a two-state folding mechanism. Here, we present a comparison of the equilibrium and kinetic folding for the HPr protein from Bacillus subtilis, E coli and a key variant ...