Browsing Colleges and Schools by Department "Neuroscience"
Now showing items 21-35 of 35
-
(2022-05-18)Opioids are among the most effective analgesics for the management of pain in the acute phase of a spinal cord injury (SCI), and approximately 80% of patients are treated with morphine in the first 24 hours following SCI. ...
-
(2018-05-01)It is known that extracellular signal-regulated kinases 1 and 2 (ERK1/2) play important roles in development and maintenance of skeletal muscles in vitro and in vivo. However, it is not clear whether muscle ERK1/2 can ...
-
(2020-05-14)Major depressive disorder (MDD) is a significant, but understudied, consequence of spinal cord injury (SCI). Approximately 11-24% of SCI patients experience MDD, compared to 8% in the general population, yet there are no ...
-
(2021-01-25)Fetal alcohol exposure is the leading non-genetic cause of neurodevelopmental disabilities. In the introduction, I first survey common genetic, epigenetic and environmental causes of neurodevelopmental disorders, and ...
-
(2022-12-05)Prenatal alcohol/ethanol exposure (PAE) can result in Fetal Alcohol Spectrum Disorders (FASD), the leading cause of intellectual disability and growth deficits, and have immediate and lifelong adverse effects on an ...
-
(2014-08-26)Spinal cord injury (SCI) leads to increased anxiety and depression in as many as 60% of patients. Yet despite extensive clinical research focused on understanding the variables influencing psychological well-being following ...
-
The Relationship Between Blood Pressure, Locomotor Performance, and Hemorrhage After Noxious Input (2017-08-16)Pain input after a spinal cord injury (SCI) has been shown to be detrimental to recovery. Animal models show that noxious input soon after injury leads to an increase in hemorrhage three hours after stimulation and long-term ...
-
(2016-08-09)Mammalian circadian rhythms are controlled by the suprachiasmatic nuclei (SCN) of the hypothalamus. While neural circuits influence SCN entrainment, cells within the SCN also act as individual oscillators. Research on ...
-
(2017-07-07)Drug abuse is strongly influenced by socio-environmental factors. Also, social environment is one of the most important predictors for adolescent drug use. In this dissertation, I examined how social housing conditions ...
-
(2020-07-01)Stress and anxiety disorders such as posttraumatic stress disorder (PTSD) pose a significant burden to the society. Existing cognitive-behavioral treatments are centered around exposure therapy which, while effective in ...
-
(2018-08-08)Fetal Alcohol Spectrum Disorders (FASDs) can result from prenatal exposure to alcohol. Alcohol is a known teratogen and in utero exposure is the leading non-genetic cause of neurodevelopmental disabilities. Neural stem ...
-
(2015-05-11)Research has shown that spinal cord injury (SCI) can induce neural hyperexcitability within the spinal cord that facilitates nociceptive reflexes. Nociceptive inputs have been shown to sensitize spinal nociceptive systems, ...
-
(2017-02-27)Anxiety and depressive disorders are the two most common types of mood disorders in the United States. These disorders are more likely to affect women than men. Animal models do not cover key aspects of mood disorders well, ...
-
(2020-04-22)Fetal alcohol spectrum disorders are a leading cause of intellectual disability worldwide. Previous studies have shown that developmental ethanol exposure results in loss of microRNAs (miRNAs) including miR-9, and loss of ...
-
(2018-05-09)Epilepsy is characterized by the occurrence of repeated unprovoked seizures. Currently there is little understanding of the pathophysiological changes in epileptogenesis, the process by which a normal brain is turned into ...