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pH modulation methods and systems for detecting binding events
(United States. Patent and Trademark Office, 2016-03-15)
Methods and systems for detecting binding between first and second molecules using a pH-sensitive fluorophore. A change in fluorescence emission intensity of the fluorophore is indicative of binding.
PH modulation method to detect ligand-receptor binding
(United States. Patent and Trademark Office, 2014-08-26)
The present disclosure relates to detecting receptor-ligand binding by measuring local pH modulation using a pH-sensitive fluorophore.