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Compositions And Use Of A Fibrinogen Binding Motif Present In EFB And COA For Therapeutics And Vaccines Against Staphylococcus Aureus
(United States. Patent and Trademark Office, 8/9/2022)
The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery ...
Targeting Of Ligand Binding Sites In ClfA
(United States. Patent and Trademark Office, 9/20/2022)
The present invention provides methods and compositions to reduce binding of fibrinogen to the ClfA in a gram positive bacterial infections using monoclonal antibody, a polyclonal antibody, an antigen-binding antibody ...
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof
(United States. Patent and Trademark Office, 2021-06-22)
The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in ...