Browsing Electronic Theses, Dissertations, and Records of Study (2002– ) by Author "Igumenova, Tatyana"
Now showing items 1-20 of 20
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Mandyoli, Lungelo (2022-02-02)Our understanding of gene essentiality in Mycobacterium tuberculosis (Mtb) has improved over the years. The introduction of these gene products into target-based drug discovery campaigns depends, in part, on whether or not ...
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Shubina-McGresham, Maria (2012-10-19)Characterization of allosteric properties of phosphofructokinase from the extreme thermophile Thermus thermophilus (TtPFK) using thermodynamic linkage analysis revealed several peculiarities. Inhibition and activation of ...
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Harshbarger, Wayne (2012-10-19)Thymidylate synthase (TS), encoded by the ThyA gene, is essential for the growth and survival of Mycobacterium tuberculosis and therefore is a potential drug target. Thymidylate synthase binds both a substrate, ...
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Moussa, Samir (2012-10-19)Like all phages, T4 requires a holin (T) to effect lysis. The lysis event depends on the temporally regulated action of T, which accumulates in the inner membrane (IM) until, at an allele-specific time, it triggers to ...
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Olson, Sara 1984- (2012-06-07)Following the passage of the United States Energy Independence and Security Act in 2007, significant progress has been made in replacing liquid fossil fuels with biofuels from lignocellulosic biomass. Many crops have been ...
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Weaver, Jeremy Scott (2015-04-28)Many essential proteins require the assistance of molecular chaperones to achieve and maintain their native, folded conformations. The E. coli GroEL-ES chaperonin system is capable of aiding the folding of the cellular ...
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Ma, Xiyu (2017-12-14)Prompt activation of pattern recognition receptors (PRRs) upon microbial infection is essential for hosts to defend against pathogen attacks. Plant Botrytis-induced kinase 1 (BIK1) family receptor-like cytoplasmic kinases ...
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Mukherjee, Keya (2018-10-24)Scientists are slowly gaining a better understanding of the composition of the gut microbiota and the role it plays in maintaining metabolic homeostasis in the host. Metagenomic sequencing of various gut microbial species ...
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Perez, Stephanie (2012-10-17)The number of allosteric sites and active sites in phosphofructokinase from Bacillus stearothermophilus create an intricate network of communication within the enzyme. With thermodynamic linkage analysis, the overall ...
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Cockrell, Allison Leigh (2013-11-27)Transition metals play essential roles in biological systems, but Fe can also be toxic to cells. In order to maintain this balance between necessity and toxicity mechanisms are employed for regulating and storing intracellular ...
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Watts, Tylan Aubrey (2013-05-16)The innate immune pathways that stimulate the expression of cytokines and proapoptotic factors in response to infection are triggered by the activation of the cytosolic receptors retinoic acid-inducible gene I (RIG-I) and ...
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Mayorov, Shanna Quinn (2012-02-14)There has been progress towards elucidating the mechanism of Escherichia coli glycerol kinase (EcGK) control by its allosteric effectors fructose-1,6-bisphosphate (FBP) and IIAglc (a member of the phosphoenolpyruvate:glycose ...
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Shen, Qingliang (2019-06-23)Influenza A virus (IAV) is the leading cause of seasonal flu epidemics. The Centers for Disease Control and Prevention (CDC) estimates that influenza viral infections cause 12,000 to 79,000 annual deaths in the United ...
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Oliver, Joel Andrew (2021-05-19)The old Western idiom “like watching grass grow” implies disinterest, apathy, and boredom. The historical etymology of this phrase is uninspired as grasses are one of the most important family of plants across the globe. ...
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Lu, Cheng (2012-10-19)RIG-I-like receptors (RLRs), RIG-I, MDA5, and LGP2, are a family of innate immune receptors that recognize viral RNA in the cytoplasm and initiate antiviral responses including the induction of type I interferons and other ...
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Smith, Aaron Gene (2012-07-16)Chloroplasts are the powerhouses of plants and also perform important storage functions. Chloroplast division is an essential process that involves proteins that are conserved from prokaryotic fission and proteins evolved ...
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Steffensmeier, Eric Michael (2016-08-22)The principal directions of this thesis involve (1) the synthesis and characterization of tetraphosphine linkers with rigid tetraphenylelement cores and derivatives thereof, (2) the study of the tetraphosphines and their ...
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Wei, Jiajie (2013-07-11)The Neurospora crassa arg-2 gene encodes the small subunit of carbamoyl phosphate synthetase, the first enzyme in fungal arginine (Arg) biosynthesis. The arginine attenuator peptide (AAP), specified by an upstream open ...
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Liu, Zhen (2013-12-09)Mycobacterium tuberculosis (M. tuberculosis) contains a wide array of genes responsible for the synthesis and secretion of a variety of bioactive lipids. The genes represent attractive drug-targets due to their involvement ...
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Harshbarger, Wayne (2015-02-09)20S proteasomes are large, multicatalytic N- terminal threonine proteases which are tasked with maintaining intracellular homeostasis by the breaking down of mis-folded, oxidized, or tagged proteins into small peptides. ...