Browsing Electronic Theses, Dissertations, and Records of Study (2002– ) by Author "Gaharwar, Akhilesh"
Now showing items 1-19 of 19
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Isaac, Alisa Helen (2022-06-23)Poly(ethylene glycol) (PEG) is a blank-slate biomaterial that is commonly used in pharmaceuticals, drug delivery, and tissue regeneration applications. However, there are growing concerns about PEG immunogenicity, and it ...
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Viswanadha, Laxmi Sai (2023-05-02)Paclitaxel (PTX) has been widely used in the treatment of non-small cell lung cancer, acute leukemia, ovarian, cervical, and breast tumors. Even though PTX was found to be therapeutically effective, due to its unfavorable ...
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Purkayastha, Purboja (2022-08-29)Mechanical properties such as pressure, viscosity and substrate stiffness are inherent components of a cell's environment. Mammalian cells respond to such mechanical cues by altering their behavior. Mechano-responsive ...
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Mitchell, Alexis (2017-07-28)The main goal of regenerative medicine is to enhance the innate healing response to more closely mimic tissue development. This may include cell-based, trophic, or small molecule therapies. In cell-based therapies, the ...
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Tigner, Thomas Jamison (2023-08-02)Hydrogels are widely used as scaffolds in tissue engineering. Designing biocompatible hydrogel platforms requires consideration of fabrication techniques and routes of administration. Click chemistries facilitate crosslinking ...
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Wilson, Scott Andrew (2017-08-01)Three-dimensional (3D) printing is an emerging approach for rapid fabrication of complex tissue structures using cell-loaded bioinks. However, 3D bioprinting has hit a bottleneck in progress due to the lack of suitable ...
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Nayak, Biswadeep (2021-12-02)High phenotypic heterogeneity in tumor cell population, especially with glioblastoma stem cells (GSCs), is one of the major causes of poor prognosis of malignant glioblastoma (GBM). Although in vivo drug screening using ...
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Whitely Jr, Michael Edward (2018-07-30)A pressing need exists to develop an improved bone replacement to treat the millions of non-union fractures that occur each year as a result of severe trauma, tumor resection, spinal fusions, and joint replacements. Current ...
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Kishan, Alysha Prem (2017-12-05)The limited availability of autografts has driven tissue engineers to fabricate synthetic grafts that temporarily replace tissue function and direct tissue regeneration. To achieve functional repair, these grafts need to ...
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Sears, Nicholas Allen (2017-06-06)Tissue grafts are often crucial in restoring function and promoting healing after traumatic injury. Many synthetic materials have been developed, but these often suffer from inadequate tissue integration, limited ...
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Lee, Hung Pang (2022-12-08)Injectable hydrogels are an important class of biomaterials for therapeutic delivery, tissue engineering, and 3D bioprinting. Owing to the complexity of medical procedures, next generation of injectable hydrogels with ...
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Li, Yixuan (2020-07-23)Nanophotonic biosensors based on plasmonic nanostructures has emerged as a promising platform for molecular diagnostics at the point-of-care. However, poor thermal stability of antibodies and numerous plasmonic nanostructures ...
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Ding, Yufang (2019-01-15)Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in western countries and characterized by a spectrum of liver injuries ranging from simple steatosis to steatohepatitis (NASH) with or ...
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Jeong, Sehoon (2018-05-09)Neurological diseases are a major challenge to reach new therapies. However, physiological signals that regulate neurodegeneration in the central nervous system (CNS) are still little known since there is no suitable in ...
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Rajeeva Pandian, Navaneeth Krishna (2021-08-25)Venous valves are anatomical structures in the veins, small and large, that help in the unidirectional flow of blood towards the heart. Unwanted clot (thrombus) formation at these valves and its subsequent complications ...
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Lalonde, Joshua Walmsley (2022-12-09)Photobiomodulation is a therapeutic technique that has been shown to aid in bone regeneration, traumatic brain injury, and wound care, among others. The main hallmark of photobiomodulation is that it uses a low-energy light ...
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Gasson, Shelby Brianne (2020-11-10)Tissue engineering holds much promise for treatment of large bone defects. The objective of the work presented herein describes the manipulation of progenitor cells known as mesenchymal stromal cells (MSCs) and three-dimensional ...
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Palma Chavez, Jorge Arturo (2020-01-08)Atherosclerosis, a condition in which plaque accumulates on the inner wall of arteries, is often recognized as a precursor to cardiovascular diseases (CVDs), the most common causes of death in the US. Optical Coherence ...
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Davis, Ryan (2022-07-25)Granular hydrogels, or densely packed microgel fragments, are an emerging class of biomaterials with tunable, attractive properties that have mainly been applied to tissue engineering and bioprinting. Here, we demonstrate ...