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Effects of Particle Size Distribution & Laser Energy Density on Selective Laser Sintered Pharmaceutical Tablets
Abstract
This research work studies the impact of particle size distribution and laser energy density on the (mechanical and pharmacokinetic) performance of pharmaceutical tablets/pills manufactured via selective laser sintering (SLS), which is a powder bed fusion additive manufacturing method. SLS of pharmaceuticals is a flexible and advantageous approach to pharmaceutical manufacturing which provides significant customizability in conjunction with game-changing advantages such as manufacturing without a solvent (which can compromise drug efficacy). Though there are recent efforts on the SLS of pharmaceuticals, there is limited investigation on how the (relative) particle size distribution of the powder mixture affects sintering and solidification behavior, and hence properties and performance. To investigate this, a systematic design of experiments is coined which investigates the influence of laser scanning speed (LSS) in conjunction with feedstock particle size distribution (PSD) on the properties/performance of the printed pill (printlet) as a function of surface temperature. Besides qualitative analysis, standardized tests including mechanical hardness testing, drug release measurement, crystallinity and degradation analysis (FTIR and XRD spectroscopy) and scanning electron microscopy are employed to elucidate the root causes that drive the processing - structure - property - performance framework. Results show that PSD and LSS have a significant impact on the printlet performance.
Subject
Selective Laser SinteringParticle Size Distribution
Laser Scanning Speed
Kollidon SR
Carbamazepine
3D printing
Powder Bed Fusion
Additive Manufacturing of Pharmaceuticals
Additive Manufacturing
Laser Energy Density
Citation
Ahmed, Abdelrahman Sabrah Sayed Noah (2023). Effects of Particle Size Distribution & Laser Energy Density on Selective Laser Sintered Pharmaceutical Tablets. Master's thesis, Texas A&M University. Available electronically from https : / /hdl .handle .net /1969 .1 /199066.
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