Evaluating the Current Status of Allergen Immunotherapy and Establishing a Basophil Activation Testing Protocol Focusing on Shrimp Allergy to Improve Oral Immunotherapy
Abstract
Allergy immunotherapy continues to be an essential treatment in the armamentarium of allergy management not only because it is the only known therapy that could modify underlying pathophysiology, but also it can lead to significant symptom and medication reduction. With recent studies of food allergy and a novel oral immunotherapy for peanut approved by the FDA in 2020, patients with food allergy have new options and allergen immunotherapy has dramatically changed their quality of life. However, questions and challenges remain, including the indication and consideration of allergen immunotherapy, identification and selection of appropriate patients for allergen immunotherapy, and lack of a comprehensive review to scrutinize the details regarding allergen immunotherapy.
In this thesis, a stepwise approach is proposed, and the results of this project are to provide (1) a comprehensive systematic review appraising allergen immunotherapy and identify important aspects and considerations and (2) a basophil activation testing protocol to enhance the accuracy and safety for allergy diagnosis and improve oral immunotherapy outcome in shrimp allergy.
Citation
Lin, Chen Hsing (2022). Evaluating the Current Status of Allergen Immunotherapy and Establishing a Basophil Activation Testing Protocol Focusing on Shrimp Allergy to Improve Oral Immunotherapy. Master's thesis, Texas A&M University. Available electronically from https : / /hdl .handle .net /1969 .1 /197090.