Nanocomposite Ionic-covalent Entanglement Reinforcement Mechanism And Hydrogel
Abstract
A biodegradable and biocompatible three dimensional construct comprising a combination of a nano silicate (e.g., laponite) and two different polymers, the two polymers each individually providing at least one covalently linked polymer chain and at least one ionically linked polymer chain, the polymeric chains forming a dual strengthening intertwined polymeric system. The constructs demonstrate improved mechanical and strength properties, while the bioinks provide a material having superior printability characteristics suitable for printing a three dimensional biodegradable construct having an aspect ratio of greater than 2.0. The bioink may also comprise cells or combinations of cells. Methods of using the constructs and bioinks for wound healing preparations and tissue regeneration are also provided.
Subject
A61L 27/222B33Y 70/00
A61L 27/26
B33Y 10/00
A61L 26/0004
A61L 26/0014
C09D 11/04
A61L 27/507
C09D 11/03
A61L 27/16
A61L 27/54
A61L 26/0023
A61L 26/0052
A61L 26/0066
A61L 27/52
A61L 26/0038
A61L 26/009
B33Y 80/00
A61L 26/0057
A61L 27/025
A61L 27/58
C09D 11/101
B29C 64/118
A61L 26/008
A61L 2300/418
B29K 2995/0056
A61L 2400/06
A61L 2300/412
A61L 2400/12
B29K 2995/006
B29K 2509/00
A61L 2400/04
C09D 11/107
B29K 2105/162
Collections
Citation
Gaharwar, Akhilesh K.; Chimene, David (8/16). Nanocomposite Ionic-covalent Entanglement Reinforcement Mechanism And Hydrogel. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /196783.