dc.creator | Koo, Ya-Ping | |
dc.creator | Hook, Magnus | |
dc.creator | Arora, Srishtee | |
dc.creator | Visai, Livia | |
dc.creator | Bertoglio, Federico | |
dc.creator | Hust, Michael | |
dc.creator | Meier, Doris | |
dc.date.accessioned | 2022-08-31T19:00:46Z | |
dc.date.available | 2022-08-31T19:00:46Z | |
dc.date.issued | 8/9/2022 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/196780 | |
dc.description.abstract | The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery pharmaceutical composition comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in inhibiting the fibrinogen binding, C3 binding, or both or administering to a subject a pharmacologically effective amount of a vaccine in a pharmaceutically acceptable excipient, comprising a modified extracellular fibrinogen binding protein comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in not shielding the staphylococcus bacterium from recognition by a phagocytic receptor. | en |
dc.language | EN | |
dc.publisher | United States. Patent and Trademark Office | en |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | Compositions And Use Of A Fibrinogen Binding Motif Present In EFB And COA For Therapeutics And Vaccines Against Staphylococcus Aureus | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | Texas A&M University System | en |
dc.contributor.assignee | Technische Universitat Braunschweig | en |
dc.contributor.assignee | Universita Degli Studi Di Pavia | en |
dc.identifier.patentapplicationnumber | 16/879272 | |
dc.date.filed | 5/20/2020 | |
dc.publisher.digital | Texas A&M University. Libraries | en |
dc.subject.cpcprimary | A61K 39/085 | |
dc.subject.cpcprimary | A61K 47/6803 | |
dc.subject.cpcprimary | C07K 16/1271 | |
dc.subject.cpcprimary | C07K 2317/565 | |
dc.subject.cpcprimary | C07K 2317/24 | |
dc.subject.cpcprimary | C07K 2317/76 | |