| dc.description.abstract | Tooth agenesis is one of the most common developmental anomalies that affect the number of teeth due to developmental failure, which requires costly dental treatment involving numerous science and public health fields. It can be seen in patients with dental caries, periodontal disease, trauma, and more specifically individuals with Down Syndrome. The emergence of regenerative dentistry challenges healthcare professionals to provide a new corrective treatment based on the mechanism of tooth development and the biological process of healing and repairing. The studied data supports that the relationship of USAG-1, antagonist to RUNX2 and BMP, have introduced a molecular targeted therapy that assists in regenerating tooth germs. BMPs and RUNX2 are transcription factors in stimulating osteoblast differentiation and demonstrate that RUNX2 can regulate BMP signaling independently on the other hand USAG-1 null mice present with supernumerary tooth formation. The manipulation of USAG-1 can benefit individuals with Down Syndrome. Infections, absence of dentitions, and craniofacial characteristics have led to difficulty chewing, swallowing, and a high occurrence of pain due to progressive periodontal disease. By taking advantage of the advancement of science and technology, it can promote the future of dentistry by stimulating the third dentition for improvement of patient care and treatment that could prolong the oral health of individuals. However, further research still has to be conducted to investigate the toxicity, teratogenicity, and tumorigenicity of these therapeutic molecules for better results. There are still more ethical concerns that will be brought up to this topic as it is being developed. | |
