| dc.creator | Hook, Magnus | |
| dc.creator | Ko, Ya-Ping | |
| dc.creator | Smeds, Emanuel | |
| dc.creator | Ganesh, Vannakambadi K. | |
| dc.date.accessioned | 2021-08-24T16:19:24Z | |
| dc.date.available | 2021-08-24T16:19:24Z | |
| dc.date.issued | 2021-06-22T00:00:00Z | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/194499 | |
| dc.description.abstract | The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual. | en |
| dc.language | EN | |
| dc.publisher | United States. Patent and Trademark Office | |
| dc.rights | Public Domain (No copyright - United States) | en |
| dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
| dc.title | Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof | en |
| dc.type | Utility patent | en |
| dc.format.digitalOrigin | reformatted digital | en |
| dc.description.country | US | |
| dc.contributor.assignee | Texas A&M University System | |
| dc.identifier.patentapplicationnumber | 16/160625 | |
| dc.date.filed | 2018-10-15T00:00:00Z | |
| dc.publisher.digital | Texas A&M University. Libraries | |
| dc.subject.cpcprimary | C07K 14/75 | |
| dc.subject.cpcprimary | C07K 16/1271 | |
| dc.subject.cpcprimary | C07K 14/31 | |
| dc.subject.cpcprimary | A61K 38/00 | |
| dc.subject.cpcprimary | C07K 2319/035 | |
