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    Mineral-based nanoparticles for arthritis treatment

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    10898445.pdf (731.6Kb)
    Date
    2021-01-26
    Author
    Gaharwar, Akhilesh K.
    Carrow, James K.
    Metadata
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    Abstract
    Aspects of the invention are directed to mineral-based nanoparticles comprising silicate nanoparticles that induce human mesenchymal stem cells (hMSCs) into a cartilage-lineage through the upregulation of cartilage-specific genes resulting in the transformation of the cell phenotype into that of a chondrocyte, i.e., a cartilage producing cell. The silicate nanoparticles are synthesized through a process where the precipitate of sodium silicate is mixed with one or more elements and compounds and milled into nanoparticles.
    URI
    https://hdl.handle.net/1969.1/193357
    Subject
    A61K 35/28
    A61K 9/5115
    A61K 35/32
    C08K 3/34
    A61K 9/0024
    A61K 9/5161
    C12N 5/0655
    A61K 9/14
    A61K 47/6923
    B82Y 5/00
    C12N 2533/10
    C12N 2506/1353
    C12N 2500/05
    C08K 2201/011
    B82Y 40/00
    Collections
    • Texas A&M University Patents
    Citation
    Gaharwar, Akhilesh K.; Carrow, James K. (2021). Mineral-based nanoparticles for arthritis treatment. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /193357.

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