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Modification of Biodegradable Mg Alloys for Biomedical Applications
Abstract
This study aimed at investigating the potential modification methods of biodegradable Mg alloy for medical implant applications.
Our study suggests enhanced antimicrobial methods as well as corrosion control methods by external coating techniques. The alloying components and coating materials are composed of non-toxic materials for future biomedical applications.
At the beginning of the study, an investigation of bacterial adhesion behaviors on Mg-4Zn-0.5Ca alloy was carried out for better understanding of bacterial adhesion mechanisms on the Mg alloy surface. Fast adhesion and propagation of bacteria were observed at the initial stage, then biofilm formation and the ruptures of bacteria were observed sequentially.
In the study on bacterial antiadhesion coatings, superhydrophobically-modified nano-SiO2 coatings confirmed strong bacterial antiadhesive properties. The direct observation of nano-SiO2 coating layers after a bacterial assay showed excellent bacterial antiadhesive properties. Another approach, for developing antibacterial coatings, environmentally friendly waterborne polyurethane/clay composite coatings were applied on the Mg alloy. The antibacterial and antiadhesive ability were systematically analyzed by various bacterial assays. The effect of oranoclays, Cloisite 25A and Cloisite 30B on bacterial species showed 99.99 % bacteria killing rate and WBPU/clay nanocomposite coatings confirmed 90 % of bacterial antiadhesive ability.
In the study on corrosion inhibition coatings, fluorinated nano-SiO2 coatings confirmed enhanced corrosion resistance for biodegradable Mg alloys. Through corrosion tests, superhydrophobic nano-SiO2 coatings showed not only corrosion inhibition but also uniform corrosion which can suppress a rapid hydrogen evolution from Mg alloy surfaces.
Subject
Biodegradable Mg alloyBiomedical implant materials
Antibacteria
Nano-silica particle
Superhydrophobic coating
Waterborne poalyurethane/clay nanocomposite
Corrosion inhibition
Citation
Son, Jaehyoung (2020). Modification of Biodegradable Mg Alloys for Biomedical Applications. Doctoral dissertation, Texas A&M University. Available electronically from https : / /hdl .handle .net /1969 .1 /193028.