Polymer/copolymer nanoparticles conjugated to gambogic acid
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A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CH.sub.2Cl.sub.2 to create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CH.sub.2Cl.sub.2:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CH.sub.2Cl.sub.2 and then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives.
Majeti, Naga Venkata Ravi Kumar; Ganugula, Raghu; Arora, Meenakshi; Saini, Prabhjot (2020). Polymer/copolymer nanoparticles conjugated to gambogic acid. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from