Regulation of Tumor Vascular Perfusion and Permeability by Endothelial Nck
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Tumor progression and metastasis is increased by the unique vasculature found in tumors which can be characterized as having low perfusion and increased permeability. The role of Nck proteins is to control actin cytoskeletal remodeling in response to signaling by tyrosine phosphorylation, which is important in developmental angiogenesis. The role of Nck in tumor angiogenesis still remains unknown. Our goal is to determine role of endothelial Nck in tumor angiogenesis and cancer progression. In order to do this, we used a syngeneic melanoma tumor model in combination with inducible, endothelial-specific deletion of Nck gene in mice. Tumor growth rate, tumor size at sacrifice were compared in both mice with and without endothelial Nck. Tumor growth rates and excised tumor size were found to be smaller in the knockout mice, which suggests that endothelial Nck facilitates tumor growth. This study aims to have an important positive impact on the subsequent development of new strategies to improve functionality in the tumor vasculature, and therefore, the efficacy of anticancer therapy.
Pedraza, Gladys (2020). Regulation of Tumor Vascular Perfusion and Permeability by Endothelial Nck. Undergraduate Research Scholars Program. Available electronically from