Mosaic chimeric viral vaccine particle
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The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
Mwangi, Waithaka; Waghela, Surya; Berghman, Luc (2019). Mosaic chimeric viral vaccine particle. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from