Compositions and methods of enhancing immune responses to enteric pathogens
Abstract
Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
Subject
A61K 39/0275A61K 39/0258
A61K 39/105
A61K 39/107
C07K 16/1232
C12N 15/85
A61K 2039/523
A61K 2039/53
C07K 2317/34
Y02A 50/474
Y02A 50/482
Collections
Citation
Bielke, Lisa; Layton, Sherryll; Hargis, Billy; Pumford, Neil R.; Faulkner, Olivia B.; Berghman, Luc; Abi-Ghanem, Daad (2019). Compositions and methods of enhancing immune responses to enteric pathogens. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177886.