Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage
Abstract
The present invention provides compositions comprising mesenchymal stem cells (MSCs), and methods for their novel use in the repair of cardiac damage and treatment of inflammatory diseases. The invention also provides methods for using TSG-6 protein that is secreted by MSCs under certain conditions, for repair of cardiac damage and inflammatory disease. The compositions of the invention may be particularly useful in restoring cardiac function following cardiac damage, including, but not limited to, myocardial infarction, as well as in reducing symptoms of inflammatory disease.
Subject
C07K 14/525C12N 5/0663
C12N 2501/25
C12N 2501/585
A61P 9/10
A61P 43/00
A61P 9/00
A61P 29/00
Collections
Citation
Prockop, Darwin J.; Lee, Ryanghwa (2018). Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177262.