Device for spectroscopic detection and monitoring of biologically relevant molecules
Abstract
There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
Subject
G01N 21/658G01N 1/34
G014N 2021/651
G01N 33/54346
G01N 33/553
B01L 3/502753
G01N 33/54326
G01N 33/54366
B01L 2300/0816
B01L 2300/0861
G01N 2001/4088
B01L 2300/0654
B01L 2300/088
Collections
Citation
Marks, Haley L.; Coté, Gerard L.; Robinson, Mitchell B.; Huang, Po-Jung; Kameoka, Jun (2018). Device for spectroscopic detection and monitoring of biologically relevant molecules. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177255.