Designer collagens and use thereof
Abstract
The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical backbone protein that facilitates wound closure comprising one or more alteration in a triple helical backbone protein sequence, that stabilize the isolated and purified triple helical backbone protein and does not disrupt an additional collagen ligand interaction; and one or more integrin binding motifs, wherein the isolated and purified triple helical backbone protein facilitates wound closure.
Subject
C07K 14/78A61L 15/325
A61L 27/24
A61L 27/507
A61L 2430/02
A61L 2430/06
A61L 2430/34
C07K 2319/00
C07K 2319/33
C07K 2319/70
Collections
Citation
Russell, Brooke H.; Hook, Magnus; Hahn, Mariah S.; Cosgriff-hernandez, Elizabeth M.; Seo, Neungseon; Xu, Marvin Xuejun; Rivera, Jose J.; Browning, Mary Beth (2017). Designer collagens and use thereof. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177215.