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    Designer collagens and use thereof

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    9725498.pdf (4.247Mb)
    Date
    2017-08-08
    Author
    Russell, Brooke H.
    Hook, Magnus
    Hahn, Mariah S.
    Cosgriff-hernandez, Elizabeth M.
    Seo, Neungseon
    Xu, Marvin Xuejun
    Rivera, Jose J.
    Browning, Mary Beth
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    Abstract
    The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical backbone protein that facilitates wound closure comprising one or more alteration in a triple helical backbone protein sequence, that stabilize the isolated and purified triple helical backbone protein and does not disrupt an additional collagen ligand interaction; and one or more integrin binding motifs, wherein the isolated and purified triple helical backbone protein facilitates wound closure.
    URI
    http://hdl.handle.net/1969.1/177215
    Subject
    C07K 14/78
    A61L 15/325
    A61L 27/24
    A61L 27/507
    A61L 2430/02
    A61L 2430/06
    A61L 2430/34
    C07K 2319/00
    C07K 2319/33
    C07K 2319/70
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    • Texas A&M University Patents
    Citation
    Russell, Brooke H.; Hook, Magnus; Hahn, Mariah S.; Cosgriff-hernandez, Elizabeth M.; Seo, Neungseon; Xu, Marvin Xuejun; Rivera, Jose J.; Browning, Mary Beth (2017). Designer collagens and use thereof. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from http : / /hdl .handle .net /1969 .1 /177215.

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