Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species
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Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
Smith, James Leif; Ravichandran, Akshaya; Lu, Shien; Gu, Ganyu (2017). Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from