Process for the enzymatic synthesis of nucleosides
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A process for synthesizing nucleosides is disclosed. The process includes the reaction of an alkylated nucleoside (such as 7-methylguanosine or 7-methylinosine) with a heterocyclic base (such as adenine, 3-deazaadenine or 1,2,4-triazole-3-carboxamide) in the presence of a nucleoside-forming enzyme to form a nucleoside that includes a glycosyl component, donate by the alkylated nucleoside, bonded to the heterocyclic base.
Wong, Chi-huey; Hennen, William J. (1991). Process for the enzymatic synthesis of nucleosides. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from