Prevention of bacterial growth and biofilm formation by ligands that act on cannabinoidergic systems
Abstract
A group of antimicrobial compounds shows effectiveness for preventing bacterial growth and bio film formation. In particular, the compounds are effective for preventing the growth of gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (“MRSA”) bacteria. The compounds include naturally-occurring compounds such as linoleyl ethanolamide, noladin ether, and anandamide, and man-made compounds such as CP55,640 [(−)-cis-3-[2-Hydroxy-4-(l,l-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol] and O-2050 [(6aR,10aR)-3-(l-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,1Oa-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran]. Because these antibacterial compounds have unique modes of action and/or unique chemical scaffolds compared to traditional antibiotics, they are extremely useful against bacteria having resistances to antibiotics.
Subject
A61K 31/352A01N 31/02
A01N 31/08
A01N 37/20
A01N 43/16
A61K 31/05
A61K 31/08
A61K 31/16
A61K 31/164
A61K 31/18
A61K 31/35
A61K 38/00
A61K 45/06
A61L 15/44
A61L 2300/30
A61L 2300/404
A61L 2300/406
A61L 4300/45
Collections
Citation
Schetz, John A.; Hoger, Sally A. (2015). Prevention of bacterial growth and biofilm formation by ligands that act on cannabinoidergic systems. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177124.