Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration
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The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes polypeptides that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties, and their application in the treatment of eye disease, particularly diseases of the retina. In particular aspects, the invention includes administration of a therapeutic polypeptide such as a stanniocalcin family member protein for the treatment of an eye disease. Also included are fusion proteins and cells stimulated or modified to express the therapeutic polypeptides as set forth herein.
Rosa, Robert; Roddy, Gavin W.; Prockop, Darwin J. (2014). Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from