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    Method for glucose monitoring using fluorescence quenching

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    8088595.pdf (1.631Mb)
    Date
    2012-01-03
    Author
    Ibey, Bennett L.
    Yadavalli, Vamsi K.
    Rounds, Rebecca M.
    Beier, Hope T.
    Cote, Gerard L.
    Pishko, Michael V.
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    Abstract
    This disclosure relates to a method of measuring a glucose concentration metric or a glucose metric in a patient by contacting an implantable glucose-sensing device with a test sample, which may be in the patient, under conditions that permit a sugar-binding molecule and a functionalized polymer or nano-particle ligand present throughout the matrix of a hydrogel to interact in a glucose-dependent manner to produce an optical signal resulting from quenching of a first fluorophore linked to the ligand or sugar-binding molecule and having a fluorescent emission spectrum quenched upon binding or release of glucose. Next the first fluorophore may be excited with light of a certain wavelength. Then at least one wavelength of light in the glucose-dependent optical signal from the fluorophore may be detected with a detector to produce a detected light signal, which may be processed to produce a glucose metric, such as a glucose concentration metric.
    URI
    https://hdl.handle.net/1969.1/176969
    Subject
    435/14
    C12Q 1/54
    G01N 33/54366
    G01N 33/53
    A61P 3/10
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    • Texas A&M University Patents
    Citation
    Ibey, Bennett L.; Yadavalli, Vamsi K.; Rounds, Rebecca M.; Beier, Hope T.; Cote, Gerard L.; Pishko, Michael V. (2012). Method for glucose monitoring using fluorescence quenching. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176969.

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