High temperature ion channels and pores
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The present invention includes an apparatus, system and method for stochastic sensing of an analyte to a protein pore. The protein pore may be an engineer protein pore, such as an ion channel at temperatures above 55° C. and even as high as near 100° C. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable electrical current signal. Possible signals include change in electrical current. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may also be detected.
Kang, Xiaofeng; Gu, Li Qun; Cheley, Stephen; Bayley, Hagan (2011). High temperature ion channels and pores. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from