dc.creator | Rich, Rebecca L. | |
dc.creator | Kriekemeyer, Bernd | |
dc.creator | Owens, Rick T. | |
dc.creator | Hook, Magnus | |
dc.creator | Murray, Barbara E. | |
dc.creator | Nallapareddy, Sreedhar R. | |
dc.creator | Weinstock, George M. | |
dc.date.accessioned | 2019-06-17T17:04:29Z | |
dc.date.available | 2019-06-17T17:04:29Z | |
dc.date.issued | 2009-12-29 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/176910 | |
dc.description.abstract | A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized to inhibit adhesion of enterococcal bacteria to extracellular matrix proteins. The N-terminal region of Ace contained a region (residues 174-319), or A domain, contains several 47-residue tandem repeat units between the collagen-binding site and cell wall-associated regions. The Ace protein can be utilized in methods of preventing and/or treating enterococcal infection, and in addition, antibodies raised against Ace, or its A domain, can be used to effectively inhibit the adhesion of enterococcal cells to a collagen substrate. | en |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | Collagen-binding proteins from enterococcal bacteria | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | The Texas A & M University System | |
dc.contributor.assignee | Board of Regents of the University of Texas System | |
dc.identifier.patentapplicationnumber | 11/102757 | |
dc.subject.uspcprimary | 424/234.1 | |
dc.subject.uspcother | 424/184.1 | |
dc.subject.uspcother | 424/190.1 | |
dc.subject.uspcother | 536/23.1 | |
dc.subject.uspcother | 536/23.7 | |
dc.date.filed | 2005-04-11 | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.subject.cpcprimary | A61K 39/02 | |
dc.subject.cpcprimary | C07K 16/1275 | |
dc.subject.cpcprimary | G01N 33/56938 | |
dc.subject.cpcprimary | C07K 16/1271 | |
dc.subject.cpcprimary | A61K 2039/505 | |
dc.subject.cpcprimary | G01N 2333/315 | |