dc.creator | Saragovi, Horacio Uri | |
dc.creator | Burgess, Kevin | |
dc.date.accessioned | 2019-06-17T16:59:13Z | |
dc.date.available | 2019-06-17T16:59:13Z | |
dc.date.issued | 2005-04-19 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/176778 | |
dc.description.abstract | Proteolytically stable small molecule β-turn peptidomimetic compounds have been identified as agonists or antagonists of neurotrophin receptors, such as TrkA. A compound of particular interest binds the immunoglobulin-like C2 region of the extracellular domain of TrkA, competes the binding of another TrkA ligand, affords selective trophic protection to TrkA-expressing cell lines and neuronal primary cultures, and induces the differentiation of primary neuronal cultures. The small β-turn peptidomimetic compounds of the invention can activate a tyrosine kinase neurotrophin receptor that normally binds a relatively large protein ligand. Such compounds that bind the extracellular domain of Trk receptors are useful pharmacological agents to address disorders where Trk receptors play a role, by targeting populations selectively. | en |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | β-turn peptidomimetic cyclic compounds | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | McGill University | |
dc.contributor.assignee | The Texas A&M University System | |
dc.identifier.patentapplicationnumber | 10/181546 | |
dc.subject.uspcprimary | 514/8.4 | |
dc.subject.uspcother | 514/21.1 | |
dc.subject.uspcother | 530/330 | |
dc.subject.uspcother | 530/331 | |
dc.date.filed | 2001-01-18 | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.subject.cpcprimary | A61K 31/00 | |
dc.subject.cpcprimary | A61K 31/395 | |
dc.subject.cpcprimary | A61K 38/12 | |